Contribution to Iontophoresis

In this paper the electrochemical background of iontophoresis is described. It is assumed that the drug introduced into the body by iontophoresis is first stored in the skin, later penetrating into deeper tissue layers. The depth of penetration is primarily independent of current desity; rather, it depends on the magnitude of the drug depot in the skin, on diffusion coefficients and on the resorption properties of the subcutaneous tissues. It is shown, that, in addition to the current-time-product, the magnitude of the current is an important parameter for iontophoresis.
Friedmann B, Stilla U, Meyer-Waarden, K (1988) Beitrag zur Iontophorese. Biomed. Technik, 33: 2-6
[ ]